HIGH URIC ACID LEVEL
Uric acid derived from purines. It usually excreted from the body by the kidney. Normal serum uric acid level is 3.5-7 mg/dl in males and 2.5-6 mg/dl in females.
PRIMARY – Uric acid level increases due to excess uric acid production in our body from purine or reduced uric acid excretion by the kidney.
Hyperuricemia usually asymptomatic and diagnosed during a routine blood test. Sometimes, uric acid forms crystals and accumulates in joints causing gout. Gout is a very painful arthritis and characterized by redness, tenderness, and swelling of the joint. Excess uric acid may accumulate in the kidney and forms a renal stone.
For an acute attack of gout, first joint pain is relieved by NSAIDs like Ibuprofen, Indomethacin, naproxen, etc. In the case of a severe gout attack, corticosteroid or colchicine is used. After remission of acute attack drugs likes to reduce uric acid allopurinol, Febuxostat is used. These drugs are xanthine oxidase inhibitors. That inhibits uric acid production in our bodies. These drugs are xanthine oxidase inhibitors that inhibit uric acid production in our bodies. Allopurinol can cause rashes and lower blood cell count. Febuxostat has toxicity to the liver. Uricosuric drugs lower serum uric acid by increasing its excretion through the kidney. Probenecid and Lesinurad are important uricosuric drugs.